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Interactive Pathways & Processes

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Resting Platelet Adhesion Receptors and GPCRs

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Adhesion Proteins

GPIb

GPIX/CD42a

Glycoprotein V/CD42d

GPIIa

GPIIIb

Fc epsilon R gamma/FCER1G

GPVI

G6b

Integrin alpha 2 beta 1

Integrin alpha 5 beta 1

Integrin alpha 6 beta 1

Integrin alpha 2b beta 3

Integrin alpha V beta 3

CD9

CD31/PECAM-1

CD36/SR-B3

CD151

CEACAM-1/CD66a

CLEC-2

ESAM

ICAM-1,2

PSGL-1/CD162

TSPAN9

GPCRs

GPR92

SUCNR1/GPR91

5-HT2A,4

alpha-2 Adrenergic R

Adenosine A2a, A2b, R

Nicotinic Acetylcholine R
alpha 7

Nicotinic Acetylcholine R
beta 2

P2Y1,12

P2X1/P2RX1

DP1/PTGDR

PTGER2,3,4

PTGIR

Thromboxane A2 R

Alternative Names for Adhesion Proteins

GPIa

GPIIa

GPIIIb

CD49b

CD29

CD36

Integrin alpha 2

Integrin beta 1

SR-B3

Resting Platelet Adhesion Receptors and GPCRs

Overview of Adhesion Receptors and GPCRs on Resting Platelets

Platelets express multiple surface proteins for adhesion to damaged vascular endothelium or to leukocytes such as monocytes and neutrophils. These include the GP family of glycoproteins, integrin heterodimers, and many others. Integrins are expressed in an inactive conformation that does not support robust adhesion until they become activated during the platelet activation process. Platelets also express G protein-coupled receptors (GPCR) that contribute to activation in response to small molecules such as thromboxanes, prostaglandins, purines, nicotinic and adrenergic ligands, adenosine, and 5-HT (serotonin).

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